PNAS에 게재된 논문

며칠 전 돼지 학교 홈페이지를 구경하다가 발견한 논문.

2009-2010년도에 시애틀 워싱턴 대학교에서 연구한 것이 이제서야 논문으로 나온 것이다.

게제 논문지명은 미국 국립과학원회보 PNAS이다.

PNAS, the official journal of the US National Academy of Sciences, is an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences. The journal is published daily online in PNAS Early Edition and weekly in print. Easily access the PNAS table of contents and full text articles directly from your mobile device.

 

(돼지야. 이건 저작권에 위배되는 것 아니지? 엄마 상식으론 논문은 다른 이들에게 많이 읽혀져야 되는 것 아닐까? 싶어서....  연구하고 논문 쓰느라 수고 많았구나.)

 

Strain-dependent diversity in the Pseudomonas aeruginosa quorum-sensing regulon PNAS 1214128109.full.pdf 2012. 09

Strain-dependent diversity in the Pseudomonas aeruginosa quorum-sensing regulon

Chugani S, Kim BS, Phattarasukol S, Brittnacher MJ, Choi SH, Harwood CS, Greenberg EP.

Quorum sensing allows bacteria to sense and respond to changes in population density. Acyl-homoserine lactones serve as quorum-sensing signals for many Proteobacteria, and acyl-homoserine lactone signaling is known to control cooperative activities. Quorum-controlled activities vary from one species to another. Quorum-sensing controls a constellation of genes in the opportunistic pathogen Pseudomonas aeruginosa, which thrives in a number of habitats ranging from soil and water to animal hosts. We hypothesized that there would be significant variation in quorum-sensing regulons among strains of P. aeruginosa isolated from different habitats and that differences in the quorum-sensing regulons might reveal insights about the ecology of P. aeruginosa. As a test of our hypothesis we used RNA-seq to identify quorum-controlled genes in seven P. aeruginosa isolates of diverse origins. Although our approach certainly overlooks some quorum-sensing-regulated genes we found a shared set of genes, i.e., a core quorum-controlled gene set, and we identified distinct, strain-variable sets of quorum-controlled genes, i.e., accessory genes. Some quorum-controlled genes in some strains were not present in the genomes of other strains. We detected a correlation between traits encoded by some genes in the strain-variable subsets of the quorum regulons and the ecology of the isolates. These findings indicate a role for quorum sensing in extension of the range of habitats in which a species can thrive. This study also provides a framework for understanding the molecular mechanisms by which quorum-sensing systems operate, the evolutionary pressures by which they are maintained, and their importance in disparate ecological contexts.

BSK 논문.full.pdf

PNAS 사이트 http://www.pnas.org/에서 검색해 보니...

며칠 전 돼지와 화상채팅하면서 캡쳐한 화면.

날씬한 돼지군, 매끼 밥 잘 챙겨 먹으시우?

시카고가 눈가뭄이라니 세계 이상 기후가 거기라고 예외는 없나 보다. 

조만간 마른 반찬 만들어서 보내 줄게.^^

(그나저나 엄마는 까막눈이다.ㅠㅠ 올해부터 영어 ABC 기초부터 다시 공부할까보다.)

BSK 논문.full.pdf

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